We use computational and experimental methods to study protein structure, function, and interactions. Our "bottom up" approach targets structurally conserved interaction domains and motifs, including coiled coils and Bcl-2 family proteins. Simple structures offer the possibility of obtaining a detailed and predictive understanding of how sequence and structure encode interaction specificity.



Designed peptides that target a key cancer protein could combat leukemia and other types of cancer.

MIT biologists have designed a new peptide that can disrupt a key protein that many types of cancers, including some forms of lymphoma, leukemia, and breast cancer, need to survive.